Genetic Therapies Show Early Promise in Treating Obesity

Scale and DNA_Taylor Tieden for BioSpace

Pictured: A scale with DNA in the background/Taylor Tieden for BioSpace 

Genetic therapies could help fight obesity, if early research at a few biopharma organizations and universities pans out. Preclinical studies indicate weight loss similar to that seen with GLP-1 agonists like semaglutide is possible but without some of the side effects, including muscle loss.

“With gene therapy, we see the potential for once-to-twice a year dosing . . . and to reduce fat, not reduce muscle,” said Paul Bolno CEO of Wave Life Sciences, which is conducting preclinical investigations into a gene therapy product for obesity.

Obesity has become a global epidemic, affecting approximately 1 billion people, according to the World Obesity Federation’s World Obesity Atlas 2024. By 2035, if current trends continue, half of the world’s adults may be obese, with the projected annual global Click here to view original post

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